000			02158cam a22003978a 4500
001			16780199
003			OSt
005			20171120101302.0
008			110512s2012 nyu b 001 0 eng
020			_a9780071603935
020			_a9781259011115
020			_a0071603948
020			_a1259011119
040			_cSA-DiMC
050	0	0	_aRM301.4 _b.S52 2012
060	1	0	_aQV 38
082	0	0	_a615.7 _222 _bAPS
100	1		_aShargel, Leon, _d1941-
245	1	0	_aApplied biopharmaceutics & pharmacokinetics / _cLeon Shargel, Andrew B.C. Yu, Susanna Wu-Pong.
246	1		_aApplied biopharmaceutics and pharmacokinetics
250			_a6th ed.
260			_aNew York : _bMcGraw-Hill, _c2012.
263			_a1212
300			_ap. ;811 _ccm.
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease.
650		0	_aBiopharmaceutics.
650		0	_aPharmacokinetics.
650	1	2	_aBiopharmaceutics.
650	2	2	_aModels, Chemical.
650	2	2	_aPharmacokinetics.
700	1		_aYu, Andrew B. C., _d1945-
700	1		_aWu-Pong, Susanna.
901			_a403
942			_2ddc _cBK
999			_c1527 _d1527